You are using an older browser that does not support current Web standards. Although this site is viewable in all browsers, it will look much better in a browser that supports Web standards.
University of Pittsburgh Academic Partner for Excellence in Environmental Public Health Tracking
Completed Epidemiology Studies
Three epidemiology/data linkage studies have been completed by UPACE and are briefly described below.
1. Cigarette Smoking and the Risk of Adult Leukemia: Results from Three Mile Island Cohort Study. Xu, Talbott, Zborowski, Rager. Archives of Environmental and Occupational Health, Fall 2007, 62 (3), p 131-138. This study evaluated the relationship between cigarette smoking and incident leukemia using pre-existing data from the Three Mile Island Cohort (1979-1995). The results from this historical prospective study suggest that cigarette smoking increases the risk of adult acute myelogenous leukemia (AML) and also demonstrate that data from existing cohorts can be used to evaluate established and/or novel environment-health effect relationships for the EPHT network. [PDF]
2. Case-Crossover Analysis of Air Pollution and Cardiorespiratory Hospitalizations: Using routinely collected health and environmental data for tracking. Xu X, Talbott E, Zborowski J, Arena V, Rager J. This study, published in a special Environmental Public Health Tracking supplement of the Journal of Public Health Management and Practice (2008 Nov-Dec; 14(6):569-76.), demonstrated that existing secondary data can be an economical source to assess the impact of point source polluters on the environmental landscape. Using a case-crossover design, Dr. Xu et al. evaluated within a spatial-temporal framework the impact of the closing of a Pittsburgh area coking facility on hospital admissions for cardiovascular and respiratory disease. Results of the study showed significant associations between the highest levels of PM10 and cardio-respiratory hospitalizations (OR: 1.12; 95% CI: 1.02-1.23) as well as cardiovascular hospitalizations only (OR: 1.13; 95% CI: 1.01-1.26) before the plant closure. The findings suggest that the closure of the LTV coke plant in Pittsburgh, PA in 1998 decreased the risk of cardiovascular disease hospitalization in the elderly living near the plant. [PDF]
3. Air Pollution Exposure during Pregnancy and Term Low Birth Weight in Allegheny County, PA 1994-2000. Xu, Talbott, Zborowski, Sharma, Arena, Rager. In this case-control study, Dr. Xu et al. explored techniques of data management, data linkage, and data analysis for environmental public health tracking to evaluate a possible association between ambient air pollution, specifically PM10, and full term low birth weight (TLBW) birth in Allegheny County, PA. Secondary existing data sources, including birth certificate data from the Allegheny County Health of Department, the EPA air monitoring data, and geographical data from the U.S Bureau of Census, were used. Logistic regression was performed to estimate the odds ratios of term low birth weight (<2500 g) per inter-quartile range increase in PM10. The results showed that the odds ratios of term LBW per inter-quartile range increase in PM10 were 1.13 (95% CI: 1.02-1.25) during the first trimester and 1.10 (95% CI: 1.00-1.22) during the second trimester, respectively, after adjustment for other important covariates. The findings of the study support the hypothesis that exposure to higher levels of PM10 is associated with increased levels of term LBW. [DOC]